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Contraindicated (one)pentobarbital will lessen the extent or outcome of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Gals should not decide on estradiol valerate/dienogest as their contraceptive though making use of sturdy CYP3A4 inducers due to prospective lower in contraceptive efficacy.I